Reduced Intracortical and Interhemispheric Inhibitions in Corticobasal Syndrome
Why this work is in the frame
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Bibliographic record
Abstract
Intracortical inhibitory and facilitatory circuits, interhemispheric inhibitory circuits and corticospinal excitability for both distal and proximal muscles were investigated in seven patients with corticobasal syndrome (CBS) and seven healthy volunteers. Transcranial magnetic stimulation was performed with surface electromyogram recorded from first dorsal interosseous muscle and biceps brachii muscle on both sides in patients and the on right side in controls. Motor thresholds and motor-evoked potential recruitment curves in both muscles at rest and during contraction were not significantly different between CBS and controls, although there was a trend for higher threshold on the more affected side in first dorsal interosseous in CBS. CBS patients had loss of short-interval intracortical inhibition bilaterally in distal and proximal muscles, reduced transcallosal inhibition from both hemispheres measured by ipsilateral silent period and paired pulse method in first dorsal interosseous, and by ipsilateral silent period in biceps brachii. Intracortical facilitation and contralateral silent period duration were not significantly changed. In conclusion, CBS patients had deficits in intracortical and interhemispheric inhibition in the representations for both distal and proximal upper limb muscles bilaterally with relative sparing of motor cortical output pathways.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it