Enhancement of Locomotor Activity and Catecholamine and 5-Hydroxytryptamine Metabolism by Thyrotropin Releasing Hormone
Bibliographic record
Abstract
I.p. administration of thyrotropin releasing hormone (TRH) twice daily for 10 days produced a dose- and time-dependent rise in spontaneous locomotor activity of young rats. A significant increase in the levels of cerebrocortical 5-hydroxytryptamine (5-HT) and dopamine (DA) also observed in animals treated with varying amounts of TRH (2, 4 and 8 mg/kg/day). The concentration of these amines was elevated after a 10 or 15 day treatment with a 4 mg/kg daily dose of TRH, but no change was observed in rats given the hormone for only 5 days. The amount of 5-hydroxyindoleacetic acid (5-HIAA) rose after a 15 day treatment; however, no significant change was seen in norepinephrine (NE) levels of any of the groups examined. The activity of brain stem tyrosine hydroxylase (TH) showed a dose-dependent increase in rats chronically treated with TRH. Although there was a significant rise in brain stem tryptophan hydroxylase (TPH) activity as well, the response was neither time- nor dose-dependent. A single injection of 200 µCi of 131I at birth induced hypothyroidism, which was accompanied by decreased brain stem TH activity. However, 5-HIAA levels were markedly enhanced in hypothyroid rats. These changes were partially reversed after a 10 day treatment with 4 mg/kg daily dose of TRH. Our data demonstrate that the rise in spontaneous locomotor activity following TRH administration in normal rats is related to altered catecholamine and possibly 5-HT metabolism brought about by this hormone. Furthermore, since TRH treatment produced similar changes in the noradrenergic system of normal and hypothyroid rats, but not in the dopaminergic or 5-hydroxytryptaminergic systems, it is suggested that part of the central effects of TRH are independent of the pituitary-thyroid axis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".