CORTICAL THINNING IN IBS: IMPLICATIONS FOR HOMEOSTATIC, ATTENTION, AND PAIN PROCESSING
Bibliographic record
Abstract
Chronic pain may be accompanied by abnormal functioning in pain, attention, or homeostatic systems. We recently identified abnormal rectal-evoked functional MRI responses in patients with irritable bowel syndrome (IBS) in brain regions associated with such systems, including the insula and anterior cingulate cortex (ACC).1 However, it is not known whether structural brain abnormalities contribute to these responses. We tested the hypothesis that abnormal cortical responses in IBS are at least partly due to structural differences within the insula and ACC. ### Methods. Right-handed healthy control subjects (n = 11, 7 women, 4 men; 24 to 50 years old) and patients with IBS (n = 9, 6 women, 3 men; 30 to 58 years old) provided written consent to procedures approved by the University Health Network Research Ethics Board. Control subjects were excluded if they had a history of bowel disorders, chronic pain, fibromyalgia, diabetes, or psychiatric illness. Patients were recruited from the Toronto Western Hospital Gastrointestinal Unit, met Rome III criteria2 for diagnosis of IBS, and had mild to moderate symptoms and pain for more than 2 years. Exclusion criteria were a history of …
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".