Structure of a group III truncated hemoglobin from<i>Camphylobacter jejuni</i>
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Bibliographic record
Abstract
Truncated hemoglobins (trHbs) build a protein family loosely related to hemoglobin, showing smaller size and extensive residue substitutions relative to conventional Hbs (< 20% sequence identity).TrHbs, widespread in unicellular organisms and in some plants, bind oxygen, and display diversified functions, including NO-detoxification.The trHb family is divided in three groups, based on amino acid sequences and evolutionary considerations.We have shown in the past that trHbs from group I and II adopt a 2-on-2 alpha-helical sandwich fold, hosting the heme [1].Moreover, a protein matrix tunnel connecting the heme to the protein surface has been identified [2].Here we present the first crystal structure of a group III trHb (from Camphylobacter jejuni, a micro-aerobic prokaryote parasite; data at 2.5 resolution, R-gen 21.9%, R-free 26.6%).We show that the trHb fold is modified mostly at the N-terminus, at the C-CD helical region, and in the matrix tunnel, that is closed and filled by core residues in this protein.We present these results at the light of evolution of the trHb and globin folds, and of the two protein families.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
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Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it