Evaluation of cisplatin treatment given concurrently with pulsed irradiation in cisplatin sensitive and resistant human ovarian carcinoma cell lines
Bibliographic record
Abstract
The aim was to investigate the effect of combined treatment of cisplatin with acute or pulsed radiation in human ovarian carcinoma cells sensitive and resistant to cisplatin. Human ovarian cancer cell parental line A2780s and a derivative cisplatin-resistant line A2780cp were given cisplatin treatment before a single acute dose irradiation or concurrently during a pulsed-dose irradiation sequence. Cells were irradiated in the confluent state, trypsinized and plated after treatment. When the combined treatment for cisplatin was given before acute irradiation, the results showed additive to superadditive effects for both cell lines. However, the superadditivity was only significant in the sensitive cell line. For the concomitant treatment of cisplatin during pulsed-dose irradiation the results were additive, except for the highest cisplatin dose in the A2780cp line where subadditivity was observed. The results indicate that the combined treatments could be clinically useful even though the results are mostly not superadditive. However, high-dose cisplatin (3 microg ml(-1)) caused a subadditive effect in the resistant cell lines for pulsed irradiation. Thus, high-dose cisplatin to overcome resistance is not effective. Cisplatin with both acute and pulsed irradiation showed additive effects indicating no advantage of using cisplatin in pulsed irradiation where sublethal damage repair may be greater.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".