Effect of Partial Dehydration of ex vivo Canine Stomach on Secretory Function
Bibliographic record
Abstract
Isolated whole canine stomachs were dehydrated for 4 h and then perfused ex vivo with homologous blood of living supporting dogs. Dehydration was produced by vacuum during which temperatures fell to –3 °C. During the perfusion period, stomachs were stimulated intra-arterially with histamine and a cholinergic drug. Blood and gastric juice (30-min samples) were studied for various components. Perfusion lasted from 6 to 8 h. The secretory function of seven dehydrated-perfused stomachs was compared with that of seven stomachs perfused without prior preservation. Dehydration resulted in loss of about one third of the gastric tissue water. When the dehydrated, hypothermic stomach was connected with normothermic homologous perfusion blood, in 30 min it regained its motility and after a 30- to 90-min ‘rest’ started to secrete titratable H+ and pepsin. In 5–8 h of perfusion, all previously dehydrated stomachs regained their water content. The perfusion method described in this study represents a model for assessing the functional viability of an organ preserved prior to transplantation. Viability and function of parietal and chief cells of the gastric mucosa was not lost, despite prolonged anoxia and marked dehydration of the whole canine stomach, as demonstrated by ex vivo perfusion.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".