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Record W2091017543 · doi:10.4088/jcp.13065su1.05

Why Are the Outcomes in Patients With Schizophrenia So Poor?

2014· review· en· W2091017543 on OpenAlexaff
Robert B. Zipursky

Bibliographic record

VenueThe Journal of Clinical Psychiatry · 2014
Typereview
Languageen
FieldMedicine
TopicSchizophrenia research and treatment
Canadian institutionsSt. Joseph’s Healthcare Hamilton
FundersH. Lundbeck A/SOtsuka AmericaOtsuka America PharmaceuticalAmgen
KeywordsSchizophrenia (object-oriented programming)PsychiatryCognitionSubstance abusePsychologyDiseaseMedicineClinical psychology

Abstract

fetched live from OpenAlex

Despite many advances in the treatment of schizophrenia over the past 50 years, the outcomes for many patients with schizophrenia remain poor. While the majority of patients with a first episode of schizophrenia may be able to achieve and maintain a remission of symptoms, only 1 in 7 patients are likely to meet criteria for recovery. These findings could be easily reconciled if schizophrenia could be established to be a progressive brain disease. Results from longitudinal studies of brain structure, cognitive functioning, and clinical outcomes, however, do not support this view. The poor outcomes so commonly observed are likely best explained by poor access to treatment, poor engagement in ongoing care, poor treatment response, and poor adherence together with the cumulative negative impact of substance abuse, comorbid psychiatric disorders, cognitive deficits, and multiple social determinants of health.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesResearch integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.633
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0040.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.003
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.062
GPT teacher head0.420
Teacher spread0.358 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations59
Published2014
Admission routes1
Has abstractyes

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