Mouse reconstructed skin from hair buds developed innervated hair follicles after grafting on athymic mice
Why this work is in the frame
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Bibliographic record
Abstract
Recovery of sensation in grafted skin is a major concern in reconstructive surgery. Because the pilosebaceaous unit represents an important tactile organ within the skin, we developed a tissue‐engineered reconstructed skin allowing the formation of complete pilosebaceous units after grafting, and we evaluated nerve regeneration. This model is based on our self‐assembly approach of tissue engineering. Sheets obtained after culturing mouse fibroblasts for 35 days with ascorbic acid, which allows collagen synthesis, are superposed. Thereafter, hair buds taken from dermis of newborn mice after collagenase digestion or freshly isolated newborn mice keratinocytes were seeded on the reconstructed dermis, cultured 10 days and grafted on athymic mice. One month after grafting, complete pilosebaceous units where obtained in reconstructed skin containing initially hair buds and were maintained up to 6 months. NF150 (neurofilaments) immunostaining revealed systematical localization of nerves around the pilosebaceous units 1 month after grafting. In contrast, nerves colonization was almost always absent when hair buds were not included in the grafted reconstructed skin. However, after 6 months, the nerves were present in both skin grafted (with or without hairs). These results suggest that the presence of hairs inside the reconstructed skin promotes nerves regeneration after grafting. Furthermore, the connection of pilosebaceous units with nerves suggests that they may be functional for the detection of the tactile stimuli.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it