Reflectance-Mode Confocal Microscopy for the Diagnosis of Sebaceous Hyperplasia In vivo
Why this work is in the frame
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Bibliographic record
Abstract
A 54-YEAR-OLD MAN WAS SEEN WITH AN ENlarging papule with central depression and telangiectasias on his left cheek. A clinical diagnosis of basal cell carcinoma was made with a differential diagnosis of sebaceous hyperplasia. We investigated the use of confocal scanning laser microscopy (CSLM) to help discriminate between these diagnoses. Imaging revealed an enlarged sebaceous lobule consisting of cuboidal cells with centrally located nuclei and a dilated sebaceous duct (Figure 1). A diagnosis of sebaceous hyperplasia was made in vivo by CSLM. Excellent confocal-histopathologic correlation was obtained confirming sebaceous hyperplasia. Two other patients with similar lesions were examined with CSLM: a 52-year-old woman with a lesion on the glabella that had an enlarged sebaceous lobule (Figure 2) and a 48-year-old man with a lesion on his left cheek that had a dilated sebaceous duct with a keratin plug (Figure 3). In these cases, CSLM provided high-resolution images of the sebaceous gland, sebocytes, and sebaceous ducts, facilitating the discrimination of sebaceous hyperplasia from basal cell carcinoma in vivo.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it