Bibliographic record
Abstract
Introduction: Gastric acid suppression is a recommended therapy for gastric ulceration. Human studies suggest that optimal healing of duodenal ulcers occurs at gastric pH >3 for 75% of the day. The objective of this study was to evaluate the efficacy of 4 gastric acid suppressants at recommended veterinary doses. Drug effect was based on the 24‐hour median pH and the percentage of time that the intragastric pH ≥3 in a 24 hour period. Methods: The study was conducted in 12 healthy Beagle dogs and was a double‐blind, randomized, multiple cross‐over comparison of a placebo (saline IV q12 h), ranitidine 2 mg/kg IV q12 h, famotidine 0.5 mg/kg IV q12 h, pantoprazole 1 mg/kg IV q24 h, and omeprazole (unblinded) ∼1 mg/kg PO q24 h. Continuous 24‐hour intragastric pH measurements were obtained via PEG tube. Prior to drug testing, 24‐hour pH measurements were recorded in fasted and fed dogs. Thereafter, dogs were fed standardized meals throughout the remainder of the study period. Drugs were administered for 1 week with a one‐week washout period between tests. Data were obtained on Day 0 (baseline), Day 2 and Day 6 of treatment. Following the randomized study, famotidine 0.5 mg/kg IV q8 h and omeprazole ∼1 mg/kg + bicarbonate q12 h via PEG tube were evaluated in 6 dogs, respectively. Appropriate statistical analyses were applied to calculate the 24‐hour median pH and percentage of time that the test drug maintained intragastric pH≥3 over 24 hours. Results: The 24‐hour median pH of fasted dogs was 4.44 vs. fed dogs 1.30 (p<0.0001). The % time pH≥3: fasted dogs 66.0% vs. fed dogs 13.3% (p<0.0001). The 24‐hour median pH was (bold denotes significance when compared to saline) ‐ saline pH 1.81, ranitidine Day 2–pH 2.53, Day 6–pH 2.05, famotidine Day 2–pH 2.83, Day 6–pH 3.68, pantoprazole Day 2–pH 3.11, Day 6–pH 3.49, omeprazole Day 2–pH 3.86, Day 6–pH 4.09. The % time pH≥3: saline 32.9%; ranitidine day 2 – 44.6%, Day 6 – 37.2%; famotidine: Day 2 – 48.9%, Day 6 – 60.1%; pantoprazole: Day 2 – 54.2%, Day 6 – 59.1%; omeprazole: Day 2 – 66.9%, Day 6 – 70.2%. The 24‐hour median pH of omeprazole + bicarbonate q12 h was 4.7 on Day 2 and 4.9 on Day 6; the % time pH ≥3 was 90.9% on Day 2 and 78.4% on Day 6, respectively. No significant difference was noted in any parameter comparing famotidine q8 h and q12 h. Conclusions: Fasted dogs had a significantly higher pH than fed dogs. Omeprazole was the only drug tested that approached the potential therapeutic efficacy for healing of duodenal ulcers when assessed by criteria for human patients. Variation existed amongst dogs in all drugs tested.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".