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Intercellular Coupling Confers Robustness against Mutations in the SCN Circadian Clock Network

2007· article· en· 707 citations· W2094589586 on OpenAlex· 10.1016/j.cell.2007.02.047

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Simulation or modellingBench or experimentalTheoretical or conceptual
Classifier consensus
Bench or experimental
Teacher imitation scores

Codex

Bench or experimental0.409
Simulation or modelling0.104
Theoretical or conceptual0.069
Observational0.004
Science and technology studies0.001
Qualitative0.001
Case report0.001
Other design0.000
Metaresearch0.000
Research integrity0.000
Bibliometrics0.000
Not applicable0.000
Scholarly communication0.000
Open science0.000
Randomized trial0.000
Non-randomized trial0.000
Meta-analysis0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000
Systematic review0.000

Gemma

Bench or experimental0.383
Simulation or modelling0.013
Not applicable0.006
Observational0.005
Science and technology studies0.003
Qualitative0.000
Case report0.000
Theoretical or conceptual0.000
Research integrity0.000
Metaresearch0.000
Randomized trial0.000
Bibliometrics0.000
Meta-epidemiology (narrow)0.000
Open science0.000
Non-randomized trial0.000
Systematic review0.000
Meta-analysis0.000
Meta-epidemiology (broad)0.000
Scholarly communication0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.028
GPT teacher head0.251
Teacher spread
0.223 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Molecular mechanisms of the mammalian circadian clock have been studied primarily by genetic perturbation and behavioral analysis. Here, we used bioluminescence imaging to monitor Per2 gene expression in tissues and cells from clock mutant mice. We discovered that Per1 and Cry1 are required for sustained rhythms in peripheral tissues and cells, and in neurons dissociated from the suprachiasmatic nuclei (SCN). Per2 is also required for sustained rhythms, whereas Cry2 and Per3 deficiencies cause o…

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