Immunologic Cross-Reactivity between Spinal Cord Protein and Myelin Basic Protein
Bibliographic record
Abstract
MyelinMyelinbasic protein-induced experimental allergic encephalitis is prevented or suppressed by pretreating guinea pigs with spinal cord protein. Although myelin basic protein and spinal cord protein do not cross-react at the antibody level, significant cross-stimulation was demonstrated in an antigen-induced lymphocyte proliferation assay. The antigen-sensitive cells were characterized as T lymphocytes in that they were immunoglobulin-negative (Ig-ve) and responded to concanavalin A. However, the level of proliferation observed in the Ig-ve population was much greater than that of undepleted cells. This suggested that there existed an immunoblobulin-bearing suppressor cell population. It was unclear whether T or B lymphocytes were responsible for this suppression in that the Ig+ve cells also responded, to some extent, to concanavalin A, indicating the presence of T cells. Nonetheless, these results suggest that a possible mechanism whereby spinal cord protein protects animals against experimental allergic encephalitis is through the induction of a population of suppressor cells which are sensitized to cross-reactive determinants.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".