Late-Appearing Abscesses after Injections of Nonabsorbable Hydrogel Polymer for HIV-Associated Facial Lipoatrophy
Bibliographic record
Abstract
The authors have indicated no significant interest with commercial supporters. Avariety of injectable fillers have been employedto correct the stigmatizing facial lipoatrophy associated with HIV infection.1,2 A novel filler is Bio-Alcamid (Bio-Alcamid, Polymekon, Milan, Italy), which has been described as an injectable ‘‘endopros-thesis.’’3 This nonbiodegradable filler is composed of 96 % water and 4 % synthetic polymer polyalkylamide and is purported to be biologically inert.3,4 Bio-Alcamid is intended for large-volume augmentation as may be necessary in hemifacial lipoatrophy (Romberg’s disease) or HIV-associated lipoatrophy.3 Bio-Alcamid is intended for injection into the subcutaneous space in a bolus form. Fibroplasia ensues around the periphery of the balloon-like im-plant creating an injectable ‘‘prosthesis.’ ’ Recent re-ports have documented the success of Bio-Alcamid for the treatment of HIV facial lipoatrophy.5,6 We report a series of five patients who have received Bio-Alcamid for HIV associated lipoatrophy and who have developed late-appearing streptococcal bacterial abscesses. In all cases the abscesses resolved with incision and drainage and antibiotic therapy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".