Un cas de papillomatose respiratoire récurrente
Bibliographic record
Abstract
Resume Objectifs : Decrire un cas clinique de papillomatose respiratoire recurrente et discuter des modalites therapeutiques adjuvantes a la chirurgie ayant ete etudiees dans cette indication. Resume du cas : Le cas presente est celui d’un jeune homme ayant recu un diagnostic de papillomatose respiratoire recurrente a l’âge de 7 ans. Malgre l’utilisation d’interferon-alpha, une progression ayant affecte le parenchyme pulmonaire a ete notee a l’âge de 24 ans. Une reponse partielle a ensuite ete objectivee avec l’utilisation de cidofovir intraveineux et en nebulisation. Plusieurs complications associees a la maladie et aux differents traitements sont survenues. Discussion : La papillomatose respiratoire recurrente est une infection chronique causee par le virus du papillome humain et caracterisee par l’apparition d’excroissances sur les voies respiratoires. Les lesions disseminees ou a evolution rapide font l’objet de differents traitements en combinaison avec la chirurgie. Le cidofovir est l’agent le plus utilise, malgre des donnees contradictoires quant a son efficacite. L’interferon-alpha est progressivement delaisse a cause de son profil d’innocuite desavantageux. Le celecoxib, l’indole-3-carbinol, l’acyclovir, le ribavirin, les retinoides et les anti-acides ont ete employes dans de petites series de cas. La prevention du virus du papillome humain par la vaccination represente une avenue therapeutique interessante pour le futur. Conclusion : Les etudes s’etant penchees sur l’efficacite des differents traitements adjuvants de la papillomatose respiratoire recurrente se limitent pour la plupart a des rapports ou a des series de cas. Le cidofovir demeure l’option therapeutique la plus citee. Abstract Objective: To describe a clinical case of recurrent respiratory papillomatosis and to discuss the adjuvant treatment strategies that have been studied for this indication. Case summary: The case presented is that of a young man with a diagnosis of recurrent respiratory papillomatosis at the age of 7 years. Despite the use of interferon-alpha, progression was observed when the pulmonary parenchyma was affected at the age of 24 years. A partial response was then observed after using intravenous and nebulized cidofovir. Many complications related to the disease and to the different treatments were observed. Discussion: Recurrent respiratory papillomatosis is a chronic infection characterized by the growth of tumors in the respiratory tract caused by the human papilloma virus. Disseminated or rapidly evolving lesions can be treated in various ways in combination with surgery. Cidofovir is most often used, despite contradicting data with regard to its efficacy. Due to the many side effects of interferon-alpha, it is progressively less used. Celecoxib, indole-3-carbinol, acyclovir, ribavirin, retinoids and antacids have been used in some case-series. In the future, vaccination against human papilloma virus represents an interesting therapeutic option. Conclusion: Studies regarding the efficacy of various adjuvant treatments are limited mostly to case reports or case series. Cidofovir remains the most frequently cited therapeutic option. Key words: Cidofovir, human papilloma virus, interferon-alpha, papilloma, recurrent respiratory papillomatosis
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".