Strong Correspondence of the Vaginal and Rectal Load of Group B Streptococci in Pregnant Women
Bibliographic record
Abstract
Background: To establish the potential role of the rectum as a reservoir for vaginal Streptococcus agalactiae (group B streptococci, GBS), both sites were sampled simultaneously and the bacterial loads of GBS were established by quantitative PCR (qPCR), for 100 pregnant women at 35 - 37 weeks of gestation. Methods: Vaginal and rectal occurrence of GBS was detected by qPCR, for 100 pregnant women at 35 - 37 weeks of gestation. DNA was extracted from vaginal (V), rectal (R) and vaginorectal (VR) swabs using the NucliSENS EasyMAG platform and cfb -qPCR, specific for GBS, was carried out for the quantification of GBS. Results: Ten women were found positive for both R and V swabs, 7 positive for R swabs only and 4 positive for V swabs only. Significant positive correlation was found between vaginal and rectal loads of GBS (r = 0.701 , P < 0.0001 ). In addition, the bacterial load of the 28 positive VR swabs (mean log10 cells/mL: 6.24, SD: 0.99; median: 5.82) was always higher than that of the V (mean: 5.72, SD: 0.87; median: 5.56) or R swabs (mean: 5.52, SD 0.72; median: 5.16) separately (P < 0.05). Conclusions: Using qPCR, significant correlation between quantities of vaginal and rectal GBS loads was established. Comparison of sampling methods indicates that VR swabbing yields higher GBS loads and 7 more positive women than separate V and R swabbing, and therefore is preferable for sample collection for GBS detection in pregnant women. doi: http://dx.doi.org/10.4021/jcgo185e
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.007 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".