Anti-RNA Polymerase III Antibodies as a Risk Marker for Early Gastric Antral Vascular Ectasia (GAVE) in Systemic Sclerosis
Bibliographic record
Abstract
We read with the greatest interest the recent article by Ingraham et al, on predictors of gastric antral vascular ectasia (GAVE) in systemic sclerosis (SSc) In a series of 28 patients with GAVE, only 1 patient was positive for anti-topoisomerase I (topo I), whereas 1 patient had anti-RNA polymerase III (RNAP III) antibodies, and 4 (all with rapidly progressive diffuse cutaneous involvement) had a speckled antinuclear antibody (ANA) pattern. These 4 patients were not tested for anti-RNAP III antibodies, but the authors considered likely that the patients in this group would have anti-RNAP III because of their typical clinical appearance and the absence of anti-topo I. They also reported that, in their clinical practice, another 4 patients with diffuse cutaneous SSc and GAVE were found to be anti-RNAP III positive. For these reasons, they raised the suggestion that anti-RNAP III antibodies may act as predictors for early development of GAVE in SSc patients 1 .
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.005 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".