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Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Opus teacher head0.012
GPT teacher head0.241
- Teacher spread
- 0.229 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
The record
- Venue
- Cancer Cell
- Topic
- Glioma Diagnosis and Treatment
- Field
- Medicine
- Canadian institutions
- McGill University Health Centre
- Funders
- National Institute of Neurological Disorders and StrokeNational Institutes of HealthDeutsche KrebshilfeMcKenna Claire FoundationDeutsches KrebsforschungszentrumAlex's Lemonade Stand Foundation for Childhood CancerNIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer ResearchBundesministerium für Bildung und ForschungCure Starts Now FoundationSt. Baldrick's Foundation
- Keywords
- BiologyHistoneChromatin immunoprecipitationMutantEpigeneticsChromatinEZH2MethyltransferaseHistone H3DNA methylationPRC2GeneGeneticsMutationGene expressionMethylationCell biologyCancer researchPromoter
- Has abstract in OpenAlex
- no