HLA-DRB1 Alleles and Rheumatoid Arthritis-related Pulmonary Fibrosis
Bibliographic record
Abstract
To the Editor: Pulmonary fibrosis is a well recognized extraarticular manifestation of rheumatoid arthritis (RA)1. Several studies have shown an association between the HLA-DRB1 gene and extraarticular manifestations of RA2,3. We analyzed the effect of the HLA-DRB1 gene and cytokine gene polymorphisms on the association of pulmonary fibrosis in Japanese patients with RA. We examined 131 adult patients with RA, who fulfilled the American Rheumatism Association 1987 revised criteria for RA4. Clinical characteristics were (mean ± SD) age at study 62.4 ± 13.0 years and disease duration 11.2 ± 4.7 years. Pulmonary fibrosis was diagnosed by chest radiograph and chest high-resolution computed tomography (HRCT). Patients with dry cough or exertional dyspnea or suspicious findings for interstitial changes in chest radiography were further investigated with HRCT at suspended end-inspiratory effort without intravenous contrast material. The abnormalities used to screen for pulmonary fibrosis were ground-glass attenuation and honeycombing defined as areas of cystic spaces with thickened walls. Patients with RA with other autoimmune … Address correspondence to Dr. K. Migita, Clinical Research Center, NHO Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8652, Japan; E-mail: migita{at}nmc.hosp.go.jp
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.011 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.008 | 0.006 |
| Insufficient payload (model declined to judge) | 0.006 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".