Panhypopituitarism Secondary to Hypothalamic Involvement in a Woman With Diffuse Large B-Cell Lymphoma
Bibliographic record
Abstract
A 50-year-old woman presented with night sweats and weight loss.Computed tomography (CT) revealed bulky adenopathy involving the mesentery (16 cm), retroperitoneum, external iliac nodes, and mediastinum.Core biopsy of the mesenteric mass disclosed diffuse large B-cell lymphoma.Bone marrow was not involved at presentation; thus, she had stage IIIB disease.She received cyclophosphamide, doxorubicin,vincristine,prednisone,andrituximab(CHOP-R)chemotherapy, and interval CT scans showed positive response.She completed six cycles of chemotherapy without incident but presented 3 weeks after the final cycle with altered mental status.Head CT (Fig 1) revealed a 1.8-cm suprasellar mass associated with surrounding edema but no midline shift.Magnetic resonance imaging (MRI; Figs 2 and 3) showed a 2.0 ϫ 1.8 cm suprasellar mass arising from the floor of the third ventricle, abutting the optic chiasm anteriorly, appearing hypothalamic in origin.The infundibulum and pituitary were within normal limits.The patient was started on dexamethasone and transferred to a tertiary care center a week later.At that time, the patient displayed personality changes but ate and drank ad libitum.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".