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Record W2100825937 · doi:10.1038/mp.2012.85

Genome-wide association study of obsessive-compulsive disorder

2012· review· en· W2100825937 on OpenAlexaff
S. Evelyn Stewart, Dongmei Yu, Jeremiah M. Scharf, Benjamin M. Neale, Jesen Fagerness, Carol A. Mathews, Paul Arnold, Patrick Evans, Eric R. Gamazon, Lisa Osiecki, Lauren M. McGrath, Stephen A. Haddad, Jacquelyn Crane, Dianne M. Hezel, C Illman, C Mayerfeld, Anuar Konkashbaev, Chunyu Liu, Anna Pluzhnikov, А. А. Тихомиров, Christopher K. Edlund, Scott L. Rauch, R. Moessner, Peter Falkai, W. Maier, Stephan Ruhrmann, HJ Grabe, Leonhard Lennertz, Michael Wagner, Laura Bellodi, Maria Cristina Cavallini, Margaret A. Richter, Edwin H. Cook, James L. Kennedy, David Rosenberg, Dan J. Stein, Sian Hemmings, Christine Löchner, Amin Azzam, Denise A. Chavira, Eduardo Fournier, Helena Garrido, Brooke Sheppard, Paula Umaña, Dennis L. Murphy, Jens R. Wendland, Jeremy Veenstra‐VanderWeele, Damiaan Denys, Rianne M. Blom, Dieter Deforce, Filip Van Nieuwerburgh, H.G.M. Westenberg, Susanne Walitza, Karin Egberts, Tobias Renner, Eurı́pedes Constantino Miguel, Carolina Cappi, Ana Gabriela Hounie, Maria Conceição do Rosário, Aline S. Sampaio, Homero Vallada, Humberto Nicolini, Nuria Lanzagorta, Beatríz Camarena, Richard Delorme, Marion Leboyer, Carlos N. Pato, Michele T. Pato, Emanuel Voyiaziakis, Peter Heutink, Daniëlle C. Cath, Daniëlle Posthuma, Johannes H. Smit, Jack Samuels, O. Joseph Bienvenu, Bernadette Cullen, Abby J. Fyer, Marco A. Grados, Benjamin D. Greenberg, James T. McCracken, Mark A. Riddle, Ying Wang, Vladimir Coric, James F. Leckman, Michael H. Bloch, Christopher Pittenger, Valsamma Eapen, Donald W. Black, Roel A. Ophoff, E Strengman, Daniele Cusi, Maurizio Turiel, Francesca Frau, Fabìo Macciardi, J. Raphael Gibbs, Andrew Singleton, Sampath Arepalli, Allissa Dillman, Luigi Ferrucci, D. G. Hernandez, Ralph J. Johnson, Dan L. Longo, Michael A. Nalls, Richard M. O’Brien, Bryan J. Traynor, Juan C. Troncoso, Marcel van der Brug, H. Ronald Zielke, Alan B. Zonderman, John Hardy, Mina Ryten, Cynthia C. Smith, Daniah Trabzuni, Robert Walker, Andrew Crenshaw, Melissa Parkin, Daniel B. Mirel, D V Conti, Shaun Purcell, Gerald Nestadt, Gregory L. Hanna, Michael A. Jenike, James A. Knowles, N J Cox, David L. Pauls

Bibliographic record

VenueMolecular Psychiatry · 2012
Typereview
Languageen
FieldPsychology
TopicObsessive-Compulsive Spectrum Disorders
Canadian institutionsHealth Sciences CentreCentre for Addiction and Mental HealthSunnybrook Health Science CentreHospital for Sick ChildrenUniversity of Toronto
FundersNational Human Genome Research InstituteNational Institute on Drug AbuseNational Center for Research ResourcesNational Institute of Neurological Disorders and StrokeMedical Research CouncilNational Institute of Mental HealthNational Institute on Alcohol Abuse and AlcoholismNational Institute on AgingNational Cancer InstituteNational Institutes of Health
KeywordsGenome-wide association studySingle-nucleotide polymorphismGeneticsSNPExpression quantitative trait lociBiologyGenetic associationQuantitative trait locusCase-control studyMedicineGenotypeGeneInternal medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.003
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0020.003
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.319
Teacher spread0.302 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations391
Published2012
Admission routes1
Has abstractno

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