Acute oxalate nephropathy induced by oral high-dose vitamin C alternative treatment
Bibliographic record
Abstract
A 59 year-old woman presented for abdominal pain, fatigue and decreased urine output. Eight months before she underwent a hysterectomy with bilateral salpingo-oophorectomy for a uterine leiomyosarcoma but was diagnosed 6 months later with local recurrence. She refused radiotherapy and palliative chemotherapy but rather preferred alternative treatment with oral high-dose vitamin C. Acute renal failure (ARF) was diagnosed (creatinine 166 versus 48 µmol/L 2 months before) and urinalysis revealed abundant calcium oxalate. Abdominal scan did not reveal renal obstruction. Renal biopsy showed extensive tubular calcium oxalate crystal deposition with some degree of acute tubular injury and mild interstitial inflammation with eosinophils (Figures 1 and and2).2). She denied any ethylene glycol ingestion and she was not known for bypass surgery or malabsorption. Hemodialysis treatments were initiated to increase creatinine and for hypervolemia but unfortunately, her condition slowly deteriorated. After 3 weeks of hemodialysis, the patient's renal function has not recovered and she was finally transferred to palliative care unit. Oxalate nephropathy is mostly seen with ethylene glycol intoxication, malabsorption or in primary hyperoxaluria. Vitamin C is metabolized into oxalate and can induce ARF by precipitation of calcium oxalate in renal tubules when excessive dose is taken. The patient reported that she was taking over 4 g of vitamin C daily during 30 consecutive days. Our case combined to recently published papers [1–3] underline the importance for clinicians to increase their awareness about this potential but easily preventable complication in patients taking high-dose vitamin C as alternative treatment. Fig. 1. Intra-tubular deposition of calcium oxalate crystals (white arrows) and acute tubular injury in adjacent tubules. H&E ×20. Fig. 2. Birefringent calcium oxalate crystals under polarized light. H&E ×20.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".