The effect of pain-free treadmill training on fibrinogen, haematocrit, and lipid profile in patients with claudication
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Bibliographic record
Abstract
OBJECTIVE: To assess the effect of pain-free treadmill training on changes of plasma fibrinogen, haematocrit, lipid profile, and walking ability in patients with claudication. DESIGN: Randomized control trial. METHODS: Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication (Fontaine stage II) were randomly assigned into the treadmill training (repetitive intervals to onset of claudication pain, three times a week) or a control group (no change in physical activity) over 3 months. Both groups performed treadmill test to assess pain-free walking time (PFWT) and maximal walking time (MWT) and had blood analyses [for haematocrit, fibrinogen, triglycerides, and cholesterol: total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL)] done at baseline and after 6 and 12 weeks of the study. RESULTS: Total and LDL cholesterol levels in the training group decreased (p < 0.05) by 14.8% and 20,5%, respectively. Significant (p < 0.05) HDL cholesterol increased (14.6%) and triglycerides decreased (19%) in the training group but changes of all these lipids were insignificant in the control group over the 3 months. Haematocrit and fibrinogen changes were insignificant in both groups. PFWT was prolonged by 109% and MWT increased by 54% in the training group (p < 0.01), but not in the control group. CONCLUSION: The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it