Metabolic Activation and Inactivation of Irinotecan when Combined with the Human Monoclonal Antibody Bevacizumab
Bibliographic record
Abstract
Purpose: This pharmacokinetic study was designed to investigate whether the co-administration of the monoclonal antibody bevacizumab (BVC) shows potential to modulate the plasma disposition of irinotecan (CPT-11) and its metabolites. Patients and Methods: Ten patients suffering from advanced colorectal cancer entered this pharmacokinetic study. Patients received CPT-11 as a 60 min i.v. - infusion (180 mg/m2, total dose 339 ± 32 mg) weekly for six weeks. BVC was administered biweekly as an intravenous 90 min infusion containing 5 mg BVC per kg body weight in 100 ml balanced sodium chloride solution. Pre-medication consisted of tropisetrone (3 mg i.v. push) and atropine (0.5 mg i.v.) one hour before CPT-11 infusion. Plasma samples were analysed during / after the first (MONO) and after the third CPT-11 infusion (BVC regimen). Results: BVC did not alter plasma disposition and pharmacokinetics of the parent compound CPT-11, but in contrary BVC appeared to lower the plasma concentrations of the metabolites SN-38, SN-38gluc and APC. Conclusion: Overall, our findings indicate that administration of BVC prior to chemotherapy showed no clinically significant impact on the pharmacokinetics and metabolic activation of CPT-11.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".