No evidence of persisting measles virus in the intestinal tissues of patients with inflammatory bowel disease
Bibliographic record
Abstract
and increased body weight appropriately. Tissue samples showed a progressive increase in the amount of cell infiltrate in the matrix (table 1, fig After 2 weeks, acute inflammation was replaced by full-thickness ingrowths of capillaries and myofibroblasts. Epithelial regeneration into the anastomosis was first seen at 2 weeks, and well-formed branching crypts were seen at 4 weeks of transplantation. Goblet cells and absorptive cells with brush border were present at 4 months of transplantation. Morphologically intact regenerated mucosa extending across the anastomosis to the grafts was observed at 6 months of transplantation. To date, there is limited literature on the bioengineered intestine. Vacanti et al, 6-8 developed a cystic structure in which neomucosa forms in a biodegradable polymer in rodents. Once formed, the neointestinal cyst is anastomosed in continuity with the native bowel without causing feeding problems, but some animals had small bare areas of the cysts that lacked neomucosa. 7 We did not report such bare areas in our model; furthermore, there was progressive growth of the neomucosa in the ADM over time. It is possible that immediate contact of the ADM scaffold with the intestinal structures and with luminal content provided trophic stimuli for the new intestinal segment. 9 Another possible factor for the observed growth in our model may be the effects of small-bowel resection on the development of neointestine. It is well known that post resection gut mucosa growth factors have a stimulatory effect on intestinal regeneration. 10 In conclusion, we have demon- strated that ADM can be successfully used as a scaffold to generate a bioartificial new intestinal segment in vivo, and we propose this method as a basis for developing new intestinal elongation techniques.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".