Asymmetry of the Uncinate Fasciculus: A Post-mortem Study of Normal Subjects and Patients with Schizophrenia
Why this work is in the frame
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Bibliographic record
Abstract
The uncinate fasciculus interconnects the anterior temporal and inferior frontal lobes. The temporal lobes show a number of anatomical asymmetries, some of which are altered in schizophrenia. This study was performed to assess the size and symmetry of the uncinate fasciculus in normal subjects and in patients with the disorder. The area, fibre density and total fibre number of left and right uncinate fasciculi were estimated using stereological methods in 21 control subjects and 17 schizophrenics. The uncinate fasciculus was found to be asymmetrical in both sexes, being 27% larger and containing 33% more fibres in the right than the left hemisphere. Of the 25 brains from which both hemispheres were available, the size asymmetry was seen in 20 subjects and the greater number of fibres in 21 subjects. There was no significant effect of schizophrenia upon the uncinate fasiculus, nor interactions of diagnosis with side or sex. We conclude that the uncinate fasciculus is larger in the right hemisphere, perhaps indicating greater right-sided fronto-temporal connectivity. The unchanged size of the fasciculus in schizophrenia contrasts with commissural tracts, which are affected in this brain series in a sex-specific manner.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it