Heparin induced thrombocytopaenia secondary to intraperitoneal heparin exposure
Bibliographic record
Abstract
Type II immune-mediated heparin-induced thrombocytopenia (HIT) is reported to occur in 2% of individuals exposed to heparin for more than 4 days [1]. HIT has been well described in haemodialysis patients with a similar incidence to non-dialysis patients [2]. Patients treated with peritoneal dialysis are not routinely exposed to heparin during dialysis, and for this reason a switch from haemodialysis to peritoneal dialysis is often considered if HIT occurs in a hemodialysis patient. Previous studies have demonstrated that intraperitoneal heparin does not produce systemic anticoagulation and it has been suggested that a combination of large molecular weight and negative charge prevent systemic absorption of heparin across the peritoneal membrane [3]. However, it is unclear as to whether the reported lack of systemic absorption across the peritoneal membrane protects against the development of HIT. This is an important consideration because in many units it is standard practice to administer intraperitoneal heparin to prevent fibrin clot formation during episodes of peritonitis. In this case report we describe for the first time, to our knowledge, a case of type II HIT in a peritoneal dialysis patient who received intraperitoneal heparin.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".