Control of the reproductive axis: Balancing act between stimulatory and inhibitory input
Bibliographic record
Abstract
As for most vertebrates, reproduction in poultry is controlled by an integrated axis [the hypothalamo-pituitary-gonadal (HPG) axis]. External and internal cues are integrated at the level of the hypothalamus to initiate gonadal recruitment and control the subsequent reproductive cycle. Until recently, it was believed that the HPG was exclusively under stimulatory control from hypothalamic gonadotropin releasing hormone (GnRH). However in 2000, the discovery of gonadotropin inhibitory hormone (GnIH), an inhibitory peptide, changed this dogma. Since then, evidence accumulated to confirm that in fact the HPG is under a dual control system with a stimulatory and an inhibitory branch. In this paper, we review the organization of this dual control system, the mechanisms controlling the synthesis and release of GnRH and GnIH, and the possible integration and interactions between the two branches to regulate pituitary gonadotropes' function. Furthermore, as light perception and photoperiod are the primary cues utilized by the poultry industry in controlled environments, special consideration was given to potential practical applications.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".