In vitro degradation of in situ crosslinkable poly(propylene fumarate-co-ethylene glycol)-based macroporous hydrogels
Bibliographic record
Abstract
The effect of crosslinking density and porosity on the degradation of macroporous hydrogels (MPHs) was evaluated in this study. MPHs were synthesized from aqueous solutions of poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)) and poly(ethylene glycol)-diacrylate (PEG-DA) with concurrent free-radical initiation and pore formation reactions involving ammonium persulfate (APS), L-ascorbic acid (AH), and sodium bicarbonate (SB). The crosslinking density was controlled by the ratio of P(PF-co-EG):PEG-DA to obtain molecular weights between crosslinks (M/sub c/) of 1000/spl plusmn/100 and 1880/spl plusmn/320 g/mol. Porosity was controlled by sodium bicarbonate and ascorbic acid concentrations and ranged between 78/spl plusmn/2 and 89/spl plusmn/3%. In vitro degradation was carried out in phosphate buffer saline (PBS) at 37/spl deg/C and a pH of 7.4. MPHs degradation was assessed at 0, 2, 4, 8, and 12-weeks by evaluating the mass loss, volume change, elastic modulus under confined compression, and porosity via /spl mu/CT. Both Mc and porosity had a significant effect on the modulus at the initial time-point. The Mc had the greatest effect on the degradation of these MPHs with percent mass loss up to 62/spl plusmn/8% after 12 weeks.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".