Effect of<i>Lactobacillus plantarum</i>299v treatment in an animal model of irritable bowel syndrome
Bibliographic record
Abstract
Lactobacillus plantarum 299v is a probiotic bacterium effective in treating symptoms of irritable bowel syndrome. A mouse model of irritable bowel syndrome (IBS) can be produced by rectal administration of 1% allyl isothiocyanate (oil of mustard) in 30% ethanol. This study examined the effect of L. plantarum 299v on colonic inflammation and motility in the oil of mustard model. L. plantarum 299v (1×109 cfu) was gavaged for up to 28 days, beginning either 7 days before (pretreatment) or 8 days after oil of mustard administration (post-treatment). Colonic interferon gamma (IFNγ) release as an assessment of the inflammatory response was measured at day 4 and day 20 following oil of mustard administration. Small intestinal transit was assessed via the dye-transit score technique at day 20. L. plantarum 299v reduced inflammation at both day 4 and day 20 and normalized intestinal transit rates in the oil of mustard murine IBS model.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".