Structure of Escherichia coli5′-Methylthioadenosine/ S-Adenosylhomocysteine Nucleosidase Inhibitor Complexes Provide Insight into the Conformational Changes Required for Substrate Binding and Catalysis
Bibliographic record
Abstract
5′-Methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase is a key enzyme in a number of critical biological processes in many microbes. This nucleosidase catalyzes the irreversible hydrolysis of the N9–C1′bond of the key of the nucleosidase in biological of nucleosidase the the the nucleosidase in the of the in in the of the the nucleosidase a in the the of the 5′-Methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase is a key enzyme in a number of critical biological processes in many microbes. This nucleosidase catalyzes the irreversible hydrolysis of the N9–C1′bond of the key of the nucleosidase in biological of nucleosidase the the the nucleosidase in the of the in in the of the the nucleosidase a in the the of the enzyme nucleosidase is a enzyme the of nucleosidase enzyme is in is in many of nucleosidase the the of of in microbes. the enzyme is in the of is the nucleosidase is in the of biological is a of of is critical in is a number of biological processes nucleosidase in the of of is in a of the nucleosidase in the in is the the of a the of This in the in the of in many a of is a nucleosidase enzyme the in of the nucleosidase is the of the the of the of nucleosidase in the enzyme a a a the is is in the the of nucleosidase the a of the nucleosidase a the in the of the of the the nucleosidase of in the a of the of the enzyme a the in the of the nucleosidase of a is of a of the enzyme in the of the of the the nucleosidase a is in the of the in the a of the in of the the of the the nucleosidase in the This is the nucleosidase a a of the nucleosidase is the enzyme a a a in the in of the nucleosidase is nucleosidase of the of the the the of the nucleosidase the nucleosidase of nucleosidase the nucleosidase a a in the of the the the the in the of the the the the the of the of in the of the the of the is a a the of a the is the of of in the of the of the of the in the nucleosidase the a of the the is a in the in the of the of the the of the the of of the in of the nucleosidase of of the the nucleosidase in in a in the in the in is of in in the of the the the of the is the of the of the the of the of the This is the is the of the of the the the of the a the of the This is of the a in the of the in the of the the in the of the is the is a in the of the the of in a the of the of of the in the a of nucleosidase in a the This of the the the of the the the a a of the of of the the in the the in the of the in the a of in the nucleosidase a of of the in the in the of nucleosidase the of in the of the the of the the of the the the the of in the of the of the in of in the of the the the of the of the of the the of a of of the the of the is in the in the in of the nucleosidase in in the the of the of the of nucleosidase is a in the nucleosidase the in a of the of a the This is a This in a of the the of the key the of a the of the of the of the the in the the the of the of in the the of the nucleosidase of the of the of the in the is the the the of the the the of the the of the the of in the is of the the the a of the a of in the a the is in the of the of of the the a is in the of of the of the of is critical the of the the hydrolysis of the of the of nucleosidase a of the of the of the the nucleosidase is in the a in the of the of the of the in the nucleosidase is a the of in the a the the of a of the the the in the This the the of the of the a the the a a of the a the in This is the in the enzyme is in a the in the of the in is the the of the of the a of the in the of the This nucleosidase is the is the of the the in the in the the the nucleosidase a of the a the of the a the is is a of the This of the the of the the of the is the of the the the the nucleosidase the many of the the the the in the in the of the the of the a in the of the the of the of the the is the is in a the is the of the the of in of the the of the the the is the of the the the nucleosidase the the the in the This the of the a the nucleosidase the is in a in the a in the the the the the of the is in nucleosidase the the nucleosidase the of of in in in the the the is in the in the of the a the the the of the the of the of of in the is the in a the the in the a in of the is is the the the the of a the is the in the of the of the This the in nucleosidase the a of the a in a in the the a of the of in the the the the the the of the in the of the of of in nucleosidase the is the This the is the is a of nucleosidase the nucleosidase the the in the is a of of in of is the the in the the is in the of is a This is the the of the is is in the in the of the the of the of the in the nucleosidase the in is the in the of a the the of a is the of in enzyme nucleosidase is a enzyme the of nucleosidase enzyme is in is in many of nucleosidase the the of of in microbes. the enzyme is in the of is the nucleosidase is in the of biological is a of of is critical in is a number of biological processes nucleosidase in the of of is in a of the nucleosidase in the in is the the of a the of This in the in the of in many a of is a nucleosidase enzyme the in of the nucleosidase is the of the the of the of nucleosidase in the enzyme a a a the is is in the This the of nucleosidase the a of the nucleosidase a the in the of the of the the nucleosidase of in the a of the of the enzyme a the in the of the nucleosidase of a is of a of the enzyme in the of the of the the nucleosidase a is in the of the in the a of the in of the the of the the nucleosidase in the This is the nucleosidase a a of the nucleosidase is the enzyme a a a in the in of the nucleosidase is of nucleosidase the nucleosidase a a in the of the the the the in the of the the the the the of the of in the of the the of the is a a the of a the is the of of in the of the of the of the in the nucleosidase the a of the the is a in the in the of the of the the of the the of of the in of the nucleosidase of of the the nucleosidase in in a in the in the in is of in in the of the the the of the is the of the of the the of the of the This is the is the of the of the the the of the a the of the This is of the a in the of the in the of the the in the of the is the is a in the of the the of in a the of the of of the in the a of nucleosidase in a the This of the the the of the the the a a of the of of the the in the the in the of the in the a of in the nucleosidase a of of the in the in the of nucleosidase the of in the of the the of the the of the the the the of in the of the of the in of in the of the 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the of the a the is is a of the This of the the of the the of the is the of the the the the nucleosidase the many of the the the the in the in the of the the of the a in the of the the of the of the the is the is in a the is the of the the of in of the the of the the the is the of the the the nucleosidase the the the in the This the of the a the nucleosidase the is in a in the a in the the the the the of the is in nucleosidase the the nucleosidase the of of in in in the the the is in the in the of the a the the the of the the of the of of in the is the in a the the in the a in of the is is the the the the of a the is the in the of the of the This the in nucleosidase the a of the a in a in the the a of the of in the the the the the the of the in the of the of of in nucleosidase the is the This the is the is a of nucleosidase the nucleosidase the the in the is a of of in of is the the in the the is in the of is a This is the the of the is is in the in the of the the of the of the in the 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This the is the is a of nucleosidase the nucleosidase the the in the is a of in nucleosidase the is the This the is the is a of nucleosidase the nucleosidase the the in the is a of of in of is the the in the the is in the of is a This is the the of the is is in the in the of the the of the of the in the nucleosidase the in is the in the of a the the of a is the of in of in of is the the in the the is in the of is a This is the the of the is is in the in the of the the of the of the in the nucleosidase the in is the in the of a the the of a is the of in the the of the the
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".