Antidepressant use during first trimester not associated with risk of major congenital malformations
Bibliographic record
Abstract
Antidepressant use during first trimester not associated with risk of major congenital malformations QUESTION Question: Does duration of antidepressant use during the first trimester of pregnancy increase the risk of major congenital malformations?People: 2329 women, pregnant between 1 January 1998 and 31 December 2002, meeting the following inclusion criteria: one diagnosis of psychiatric disorder before pregnancy (ICD-9); antidepressant use for 30 days or more in the year prior to pregnancy; aged 15-45 years at the beginning of pregnancy; and live or still birth at the end of pregnancy.Women were identified using three administrative databases of the Province of Quebec (RAMQ, MED-ECHO and ISQ databases).Mailed questionnaires were used to elicit information on confounding variables such as income, education, ethnicity and lifestyle factors.Exclusion criteria: women with mental retardation, certain psychotic or non-psychotic conditions; abortion and miscarriage.Setting: Province of Quebec, Canada; recruitment January 1998-
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".