The incidence and impact of lupus anticoagulants among patients in the intensive care unit
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
oagulation abnormalities are commonly encountered in critically ill patients. Thus, intensivists are often challenged by the finding of prolonged activated partial thromboplastin time (APTT) in the setting of a normal international normalize ratio (INR). Potential causes of this presentation include heparin, a specific coagulation factor inhibitor, or a non-specific inhibitor, also known as a lupus anticoagulant (LA). Lupus anticoagulants are one of the 2 cardinal types of antiphospholipid antibodies. The presence of an antiphospholipid antibody (APA) in concern with venous or arterial thrombosis or recurrent pregnancy loss defines the antiphospholipid antibody syndrome (APS).1 Antiphospholipid antibody syndrome is either identified using a coagulation assay for LA or by detection of an anticardiolipin antibody using a specific enzyme-linked immunosorbent assay.1 Lupus anticoagulants are antibodies that interfere with one or more phospholipid-dependent activated partial throm-boplastin assays.2 Other APA have been identified; these include antibodies directed against pro-thrombin or one a variety of anionic cell surface glycoproteins. Despite their name LA antibody are associated with thromboembolic events rather than clinical bleeding.1 Approximately one third of individual with LA suffers with arterial or venous thrombosis or recurrent pregnancy loss.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it