Effects of Soy Phytoestrogens Genistein and Daidzein on Breast Cancer Growth
Bibliographic record
Abstract
AbstractOBJECTIVE:To determine whether genistein and daidzein, the major phytoestrogens in soy, can stimulate breast cancer growth.DATA SYNTHESIS:Systematic search through primary English-language literature on MEDLINE (1966–January 2001), EMBASE (1982–January 2001) and Current Contents (1998–January 2001).DATA SOURCES:Genistein and daidzein at low concentrations were found to stimulate breast tumor growth in in vitro and in vivo animal studies, and antagonize the antitumor effect of tamoxifen in vitro. At high concentrations, genistein inhibited tumor growth and enhanced the effect of tamoxifen in vitro.CONCLUSIONS:Genistein and daidzein may stimulate existing breast tumor growth and antagonize the effects of tamoxifen. Women with current or past breast cancer should be aware of the risks of potential tumor growth when taking soy products. ResumenOBJETIVO:Determinar si genistein y daidzein, los fitoestrógenos contenidos en productos de soya, pueden estimular el crecimiento de las células cáncerosas en el cáncer del seno.SÍNTESIS DE:Se realizó una búsqueda sistématica de la literatura biomédica en inglés utilizando la base de datos de MEDLINE, EMBASE, y Current Contents.FUENTES DE DATOS:Genistein y daidzein a concentraciones bajas pueden estimular el crecimiento de tumors en el seno in vitro e in vivo en animales y antagonizan los efectos del tamoxifeno in vitro. En altas concentraciones, genistein inhibe el crecimiento del tumor y potencia el efecto de tamoxifeno in vitro.CONCLUSIONES:Genistein y daidzein pueden estimular el crecimiento del tumor en el cáncer del seno y antagonizar el efecto de tamoxifeno. Las mújeres con cáncer del seno o historial de cáncer del seno deben ser informadas del possible riesgo que los productos de soya pueden tener en el crecimiento del tumor o de las células cáncerosas. RésuméOBJECTIF:Déterminer si les principaux phytoestrogènes du soja (génistein et daidzein) peuvent stimuler la croissance des cancers du sein.REVUE DE LITTÉRATURE:Il a été conduit une recherche systématique de la littérature primaire en anglais sur MEDLINE, EMBASE, et Current Contents.RÉSUMÉ:A faibles concentrations, génistein et daidzein stimulent la croissance des tumeurs mammaires in vitro comme chez l'animal et antagonisent l'effet antitumoral du tamoxifène in vitro. A fortes concentrations (plus de 10 μM), le génistein inhibe la croissance tumorale et renforce l'effet du tamoxifène in vitro.CONCLUSIONS:Aux doses susceptibles d'être consommées en pratique, génistein et daidzein peuvent stimuler la croissance des cancers du sein et inhiber l'effet du tamoxifène. Les femmes ayant ou ayant eu un cancer du sein devraient être informées du risque de croissance tumorale lié à la consommation de produits extraits du soja.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.002 |
| Bibliometrics | 0.004 | 0.005 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".