Environmental ‘Low Dose’ Mesotheliomas and Their Relationship to Domestic Exposures-Preliminary Report
Bibliographic record
Abstract
Crocidolite is a fibrous mineral with unusual crystallography in that the fiber width varies according to geographical origin. The fibers from the mining areas of Western Australia and the Cape Province, in South Africa are ‘thin’ compared to those from Bolivian and some other mines. Regardless, the mineral is a well known causative agent for mesothelioma. The literature contains many reports of the disease occurring as a consequence of so called environmental exposures due to what some believe to be ‘low’ dose, ambient exposure. However, closer examination of these exposure conditions generally reveals an unrecognized (or simply ignored) strong domestic (para-occupational) exposure component. Oftentimes, the importance of such domestic exposures is not considered since they too are thought to be too low to contribute to risk. We have, for the first time, applied state of the art measurement methods to evaluate domestic (shake out) conditions created by workers in a historical unregulated crocidolite-cement based operating plant in Bolivia. Our results show that exposures can reach levels more usually associated with historic occupational exposures. The reason for studying the exposures in such a plant is that epidemiological studies have shown that ‘thin’ crocidolite fibers are associated with a high mesothelioma risk while exposure to the ‘thick’ Bolivian fibers are associated with a much lessened mesothelioma risk.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".