Hypercalcaemia in a patient with membraneous nephropathy
Bibliographic record
Abstract
1From the Nephrology Group, L'Hôtel-Dieu de Québec Institution, Department of Medicine, Faculty of Medicine, Laval University, Québec G1R 2J6 and 2From the Endocrinology Group, Saint-Luc Hospital, Department of Medicine, Faculty of Medicine, Montreal University, Montreal H2X 3J4, Canada We report the case of a man who was investigated at the age of 23 for hypercalcaemia. This disorder not only occurred in the setting of multiple diseases that can alter calcium balance, but also in the setting of unique nosological associations. The case presented here was therefore, a challenging problem to solve and it proved to be a great learning opportunity. At 23 years of age, in May 2001, a Caucasian male consulted his family doctor for asthenia, weight loss, hand tremor, palpitations, polyuria, polydipsia, gynaecomastia and galactorrhoea, all of which developed progressively over a few months. At the time of consultation, he was on nifedipine, metoprolol, pravastatin and aspirin. His past medical history included a membraneous nephropathy that was diagnosed at the age of 15 (November 1992) and which was complicated by chronic, non-progressive renal failure, persistent proteinuria between 5–10 g per day and high blood pressure. The inquiry was otherwise negative and the patient denied using any non-prescription drugs, vitamin supplements, isotretinoin or lithium salts. A physical examination in May 2001 revealed a blood pressure of 154/92 mmHg, a heart rate of 100/min, a slightly enlarged thyroid gland and mild bilateral gynaecomastia. For the rest, the secondary sexual characters were normal, there was no ankle oedema, and the patient's weight and height were 57 kg and 170 cm, respectively.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".