Hormonal Regulation of Circulating C-Reactive Protein in Men
Bibliographic record
Abstract
The plasma concentration of C-reactive protein (CRP), measured by high-sensitivity methods, is a reliable marker of risk of future coronary heart disease (CHD) in healthy individuals (1)(2) and of CHD death in patients with unstable angina pectoris or non-Q-wave myocardial infarction (3). The possibility of hormonal regulation of circulating CRP is of great interest because male gender is considered an independent risk factor for CHD and estrogen has many beneficial cardiovascular effects in women (4). Both in vivo and in vitro data support the hypothesis that interleukin-6 (IL-6) is the main inducer of the acute-phase CRP response, but other factors such as IL-1β might potentiate IL-6 stimulation of CRP (5). The factors determining unstimulated CRP expression are less known. Because of the strong association between CRP and CHD and the fact that previous studies have shown that CRP to a large extent is regulated on the transcriptional level (5), it is of great interest to identify factors that regulate CRP production. A study of randomized treatment of prostate cancer by orchidectomy or estrogen allowed us to investigate the hormonal influence on circulating CRP concentrations in middle-aged and elderly men.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".