MétaCan
Menu
Back to cohort
Record W2121906867 · doi:10.1038/nature08987

International network of cancer genome projects

2010· article· en· W2121906867 on OpenAlexaff
Fabien Calvo, Iiro Eerola, Daniela S. Gerhard, Alan F. Guttmacher, Mark S. Guyer, Jennifer L. Jennings, David Kerr, Peter Klatt, Patrik Kolar, David P. Lane, Frank Laplace, Gerd Nettekoven, Brad Ozenberger, T. S. Rao, Jacques Remacle, Tatsuhiro Shibata, Joseph G. Vockley, Koichi Watanabe, Huanming Yang, M.M.F. Yuen, Martin Bobrow, Anne Cambon‐Thomsen, Lynn G. Dressler, Yann Joly, Pilar Nicolás, Michael Parker, Emmanuelle Rial‐Sebbag, Carlos M. Romeo-Casabona, Susan Wallace, Georgia L. Wiesner, Nikolajs Zeps, Christian Chabannon, Bruno Clément, Françoise Degos, Peter Geary, D. Neil Hayes, Thomas J. Hudson, Amber L. Johns, Hidewaki Nakagawa, Miguel Á. Piris, Rajiv Sarin, Aldo Scarpa, Marc J. van de Vijver, P. Andrew Futreal, Hiroyuki Aburatani, Mónica Bayés, Xavier Estivill, Sean M. Grimmond, Martin Hirst, Marco A. Marra, John D. McPherson, Zemin Ning, Yijun Ruan, Harold Swerdlow, Victor E. Velculescu, Liu Yang, Gary D. Bader, Paul C. Boutros, Paul Flicek, Gad Getz, Roderic Guigó, Guangwu Guo, David Haussler, Tao Jiang, Qibin Li, Ruibang Luo, B. F. Francis Ouellette, John V. Pearson, Xosé S. Puente, Vı́ctor Quesada, Benjamin J. Raphael, Chris Sander, Terence P. Speed, Joshua M. Stuart, Yasushi Totoki, Honglong Wu, Shancen Zhao, Guangyu Zhou, Paul T. Spellman, Teruhiko Yoshida, Myles Axton, Linda J. Miller, Junjun Zhang, Syed Haider, Jianxin Wang, Christina K. Yung, Anthony Cross, Yong Liang, Saravanamuttu Gnaneshan, Jonathan M. Guberman, Jack Shih‐Chieh Hsu, Drc Chalmers, Karl W. Hasel, Terry Sheung-Hung Kaan, William W. Lowrance, Tohru Masui, Laura Lyman Rodriguez, Catherine Vergely, David D.L. Bowtell, Nicole Cloonan, Anna DeFazio, James R. Eshleman, Dariush Etemadmoghadam, Brooke A. Gardiner, James G. Kench, Robert L. Sutherland, Margaret A. Tempero, Peter J. Wilson, Steve Gallinger, Patricia Shaw, Gloria M. Petersen, Debabrata Mukhopadhyay, Sarah P. Thayer, Kamran Shazand, Timothy Beck, Michelle Sam, Lee E. Timms, Vanessa Ballin, Youyong Lu, Jiafu Ji, Xiuqing Zhang, Feng Chen, Xueda Hu, Qi Yang, Geng Tian, Lianhai Zhang, Xiaofang Xing, Xianghong Li, Zhenggang Zhu, Yingyan Yu, Jun Yu, Mark Lathrop, Jörg Tost, Paul Brennan, Ivana Holcátová, Давид Заридзе, Alvis Brāzma, Egor Prokhortchouk, Rosamonde E. Banks, Mathias Uhlén, Juris Vīksna, Fredrik Pontén, Konstantin Skryabin, Ewan Birney, Ake Borg, Carlos Caldas, Sancha Martin, Jorge S. Reis-Filho, Andrea L. Richardson, Christos Sotiriou

Bibliographic record

VenueNature · 2010
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCancer Genomics and Diagnostics
Canadian institutionsBC Cancer AgencyHospital for Sick ChildrenLunenfeld-Tanenbaum Research InstituteToronto General HospitalMcGill University and Génome Québec Innovation CentreUniversity of British ColumbiaMcGill UniversityCanada's Michael Smith Genome Sciences CentreGenome CanadaUniversity Health NetworkUniversity of TorontoCanadian Women's Health NetworkOntario Institute for Cancer Research
FundersNational Institute of Diabetes and Digestive and Kidney DiseasesNational Cancer InstituteNational Human Genome Research InstituteWellcome Trust
KeywordsGenomeCancerBiologyComputational biologyGenomicsGeneticsGene

Abstract

fetched live from OpenAlex

Hundreds of individual human cancer genome sequences are expected to be published in 2010, and thousands per year after that. The International Cancer Genome Consortium (ICGC) was launched with the aim of keeping track of the data relating to large-scale cancer genome studies of all major cancers in adults and children — a total of 50 different cancer types and/or subtypes. In this issue the ICGC team ( http://www.icgc.org ) spells out the policies and planning for the project. The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.007
metaresearch head score (Gemma)0.012
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.066
Threshold uncertainty score0.221

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0070.012
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0120.026
Science and technology studies0.0020.001
Scholarly communication0.0040.001
Open science0.0030.005
Research integrity0.0020.004
Insufficient payload (model declined to judge)0.0660.034

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.262
Teacher spread0.258 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2,415
Published2010
Admission routes1
Has abstractyes

Explore more

Same venueNatureSame topicCancer Genomics and DiagnosticsFrench-language works237,207