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Record W2122249218 · doi:10.1053/j.gastro.2011.04.057

Single Nucleotide Polymorphisms That Increase Expression of the Guanosine Triphosphatase RAC1 Are Associated With Ulcerative Colitis

2011· article· en· W2122249218 on OpenAlexafffund
Aleixo M. Muise, Thomas D. Walters, Wei Xu, Grace Shen‐Tu, Conghui Guo, Ramzi Fattouh, Grace Y. Lam, Victorien M. Wolters, Joshua D. Bennitz, Johan Van Limbergen, Paul Renbaum, Yair Kasirer, Bo‐Yee Ngan, Dan Turner, Lee A. Denson, Philip M. Sherman, Richard H. Duerr, Judy H. Cho, Charlie W. Lees, Jack Satsangi, David C. Wilson, Andrew D. Paterson, Anne M. Griffiths, Michael Glogauer, Mark S. Silverberg, John H. Brumell

Bibliographic record

VenueGastroenterology · 2011
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicProtein Tyrosine Phosphatases
Canadian institutionsPrincess Margaret Cancer CentreHospital for Sick ChildrenUniversity of TorontoMount Sinai HospitalSickKids Foundation
FundersAction Medical ResearchOntario Ministry of Research and InnovationCanadian Institutes of Health ResearchMedical Research CouncilCanadian Child Health Clinician Scientist ProgramNational Institute of Diabetes and Digestive and Kidney DiseasesCrohn's and Colitis Foundation of CanadaCrohn's and Colitis FoundationCanadian Association of GastroenterologyScottish GovernmentHospital for Sick ChildrenWellcome Trust
KeywordsGuanosineUlcerative colitisSingle-nucleotide polymorphismTriphosphataseNucleotideRAC1BiologyChemistryGeneticsGeneMedicineInternal medicineGenotypeDisease

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.205
Teacher spread0.190 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations71
Published2011
Admission routes2
Has abstractno

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