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Record W2122526789 · doi:10.1109/iembs.2008.4649702

Effects of an improved auditory-periphery model on the response properties of modeled neurons in the Dorsal Cochlear Nucleus

2008· article· en· W2122526789 on OpenAlexaff
Stephen Vetsis, Xiaohan Zheng, Herbert Voigt, Ian C. Bruce

Bibliographic record

Venuenot available
Typearticle
Languageen
FieldNeuroscience
TopicHearing, Cochlea, Tinnitus, Genetics
Canadian institutionsMcMaster University
Fundersnot available
KeywordsDorsal cochlear nucleusCochlear nucleusNucleusNeuroscienceStimulus (psychology)ExcitationDorsumBiological systemCochlear nerveAuditory systemPhysicsChemistryCochleaAnatomyBiologyPsychology

Abstract

fetched live from OpenAlex

Dorsal Cochlear Nucleus (DCN) neurons were simulated using two different models of auditory nerve (AN) fibers as inputs, the Carney model [1] and the Zilany & Bruce model [2], [3]. The change of AN models produced very different responses. DCN neurons simulated using the Zilany and Bruce model had much greater regions of excitation and significantly reduced regions of inhibition. Further investigation into the differences between the two AN models revealed that the broadened tuning of the auditory nerve fibers produced by the Zilany & Bruce model at higher stimulus intensities coupled with the lower excitation thresholds accounted for the discrepancies. Changes in DCN model connection parameters and their effects on the resulting simulated neurons were then explored in an attempt to provide a qualitative framework for determining a set of DCN parameters capable of reproducing physiological responses using the Zilany and Bruce AN fiber model. A mix of increased W-cell inhibition to narrow the response of type-II cells and changes in AN connection parameters to increase their excitability at higher intensities were found to be required to reproduce physiological response properties. These changes in the type-II cell response would provide adequate compensation for the increased excitation and broadened responses at higher intensities observed in DCN model P-cells.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.012

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.050
GPT teacher head0.249
Teacher spread0.199 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2008
Admission routes1
Has abstractyes

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