Genetically modified growth affects allometry of eye and brain in salmonids
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Effects of growth acceleration on eye development have been examined in genetically modified salmonids. Growth hormone (GH) transgenic coho salmon ( Oncorhynchus kisutch (Walbaum, 1792)) show dramatically elevated overall body growth and an absolute increase in eye size, but relative eye growth is shifted from negatively allometric to more isometric. Thus, transgenic fish possess significantly smaller eyes relative to nontransgenic fish of the same size. Ration-restricted limitation of growth in transgenic salmon to that of wild type restores relative eye growth rate, suggesting that effects on eyes are an indirect consequence of modification of growth rate rather than a direct effect of GH overexpression. Heart, spleen, and liver did not show changes in proportion among groups, whereas total brain size showed the same response as eye. Relative eye and brain size were also reduced in a fast-growing domesticated strain of rainbow trout ( Oncorhynchus mykiss (Walbaum, 1792)), suggesting modifications of allometry are a more general effect of growth acceleration. GH mRNA levels from the transgene were elevated in eyes, whereas IGF-I mRNA was not, suggesting this organ may be regulated in a different fashion than other organs. Neural tissues with critical structural requirements for optimal function may be subject to less modification of growth rate than are other organ systems.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it