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Record W2122791877 · doi:10.1038/ng.572

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

2010· review· en· W2122791877 on OpenAlexaff
Jason Z. Liu, Federica Tozzi, Dawn Waterworth, Sreekumar Pillai, Pierandrea Muglia, Lefkos Middleton, Wade H. Berrettini, Christopher W. Knouff, Xin Yuan, Gérard Waeber, Péter Vollenweider, Martin Preisig, Nicholas J. Wareham, Jing Hua Zhao, Ruth J. F. Loos, Inês Barroso, Kay‐Tee Khaw, Scott M. Grundy, Philip J. Barter, Robert W. Mahley, Antero Kesäniemi, Ruth McPherson, John B. Vincent, John S. Strauss, James L. Kennedy, Anne Farmer, Peter McGuffin, Richard Day, K. Matthews, Per Bakke, Amund Gulsvik, Susanne Lucae, Marcus Ising, T. Brueckl, Sonja Horstmann, H‐Erich Wichmann, Rajesh Rawal, Norbert Dahmen, Claudia Lamina, Ozren Polašek, Lina Zgaga, Jennifer E. Huffman, Susan Campbell, Jaspal S. Kooner, John C. Chambers, Mary Susan Burnett, Joseph M. Devaney, Augusto D. Pichard, Kenneth M. Kent, Lowell Satler, Joseph Lindsay, Ron Waksman, Stephen E. Epstein, James F. Wilson, Sarah H. Wild, Harry Campbell, Véronique Vitart, Muredach P. Reilly, Mingyao Li, Liming Qu, Robert Wilensky, William Matthai, Håkon Håkonarson, Daniel J. Rader, André Franke, Michael Wittig, Arne Schäfer, Manuela Uda, Antonio Terracciano, Xiangjun Xiao, Fabio Busonero, Paul Scheet, David Schlessinger, David St Clair, Dan Rujescu, Gonçalo R. Abecasis, Hans J. Grabe, Alexander Teumer, Henry Völzke, Astrid Petersmann, Ulrich John, Igor Rudan, Caroline Hayward, Alan F. Wright, Ivana Kolčić, Benjamin J. Wright, John R. Thompson, Anthony J. Balmforth, Alistair S. Hall, Nilesh J. Samani, Carl A. Anderson, Tariq Ahmad, Christopher G. Mathew, Miles Parkes, Jack Satsangi, Mark J. Caulfield, Patricia B. Munroe, Martin Farrall, Anna F. Dominiczak, Jane Worthington, Wendy Thomson, Anne Barton, Vincent Mooser, Clyde Francks, Jonathan Marchini

Bibliographic record

VenueNature Genetics · 2010
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCancer-related molecular mechanisms research
Canadian institutionsUniversity of TorontoCentre for Addiction and Mental HealthUniversity of Ottawa
FundersNational Institute on AgingNational Institutes of HealthUniversity of OxfordNational Institute on Drug AbuseGlaxoSmithKline
KeywordsImputation (statistics)BiologyLocus (genetics)Genome-wide association studyGenetics1000 Genomes ProjectGenetic associationSingle-nucleotide polymorphismSNPMeta-analysisPopulationGeneGenotypeStatisticsInternal medicineMedicineEnvironmental healthMissing data

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.014
metaresearch head score (Gemma)0.017
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.014
Threshold uncertainty score0.072

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0140.017
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0070.005
Bibliometrics0.0020.004
Science and technology studies0.0000.001
Scholarly communication0.0020.001
Open science0.0040.001
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.352
Teacher spread0.318 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations618
Published2010
Admission routes1
Has abstractno

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