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Record W2122941573 · doi:10.1076/phbi.39.6.408.5880

Phytochemistry and Antibacterial Activity of Senna alata Flower

2001· article· en· W2122941573 on OpenAlex
Otunola Adedayo, William A. Anderson, Murray Moo‐Young, Victor Snieckus, Pradeep A. Patil, Deboye O. Kolawole

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenuePharmaceutical Biology · 2001
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicPhytochemistry and biological activity of medicinal plants
Canadian institutionsUniversity of Waterloo
FundersNatural Sciences and Engineering Research Council of CanadaDirectorate for Biological Sciences
KeywordsMicrococcus luteusPhytochemistryProteus vulgarisMicrobiologyBiologyMinimum bactericidal concentrationSerratia marcescensEnterococcus faecalisMinimum inhibitory concentrationAntibacterial activityPseudomonas fluorescensAntimicrobialProteus mirabilisPenicillinStaphylococcus aureusBacillus subtilisTraditional medicineEscherichia coliBacteriaBotanyAntibioticsBiochemistry

Abstract

fetched live from OpenAlex

Phytochemistry and antibacterial potency of some crude and partially purified fractions of Senna alata flower was examined against 22 bacterial strains. The crude plant extracts, containing steroids, anthraquinone glycosides, volatile oils and tannins, exhibited a high minimum inhibitory concentration of 500 µg/mL against Staphylococcus aureus, Streptococcus faecalis, Micrococcus luteus, Bacillus subtilis and Pseudomonas putida, but was generally inactive against Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Serratia marcescens, and Pseudomonas fluorescens (above 1000 µg/mL). However, the partially purified plant extract was bacteriostatic at a low concentration of 100 µg/mL, with a minimum bactericidal concentration of 500 µg/mL, primarily against the Gram positive organisms. At a concentration slightly above the minimum inhibitory concentration, the purified extract was nearly as potent as standard antibiotics, exhibiting zones of bacterial growth inhibition ranging from 10 to 25 mm, even against multiple antibiotic resistant local isolates that were not susceptible to methicillin, penicillin and streptomycin.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.102
Threshold uncertainty score0.815

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.045
GPT teacher head0.305
Teacher spread0.260 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it