PL-7 Positive Antisynthetase Syndrome and Pulmonary Hypertension
Bibliographic record
Abstract
To the Editor: Antisynthetase syndrome is characterized by interstitial lung disease (ILD), myositis, arthropathy, fever, Raynaud phenomenon, and mechanic’s hands. The morbidity of the syndrome is usually due to lung involvement1. In January 2005, a 65-year-old female nonsmoking patient presented to our outpatient clinic with fever (38.5°C), unproductive cough, shortness of breath, dry throat, nocturnal sweating, and weight loss (3–4 kg). Previously, she was exposed to passive cigarette smoke and cleaning chemicals. Essential hypertension treated by bisoprolol and an allergy to contrast material were known. There was no positive family history for rheumatic or cardiovascular disease. Electrocardiogram was normal but lung function test showed a restrictive pattern [forced vital capacity (FVC) 52%, forced expiratory volume (FEV)1 56.3%, FEV1/FVC 85.1%]. Carbon monoxide diffusion capacity measurement was not feasible because of the decreased vital capacity. Glomerular filtration rate was slightly reduced (48 ml/min). Other variables were elevated: C-reactive protein 18 mg/l (normal < 5 mg/dl), creatine kinase (CK) 1402 U/l, CK-myocardial band 45 U/l, lactate dehydrogenase 335 U/l, and pro-brain natriuretic peptide (NT-proBNP) 426 pg/ml. Antinuclear antibodies (ANA) were negative. Chest radiograph showed cardiomegaly and pulmonary reticulonodular pattern (Figure 1A). Chest … Address correspondence to Dr. H. Olschewski, Medical University of Graz, Department of Internal Medicine, Division of Pulmonology, A-8036 Graz, Auenbruggerplatz 20, Austria. E-mail: horst.olschewski{at}klinikum-graz.at.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.007 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.008 | 0.008 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".