Neonatal Brain: Regional Variability of in Vivo MR Imaging Relaxation Rates at 3.0 T—Initial Experience
Bibliographic record
Abstract
PURPOSE: To retrospectively investigate regional in vivo magnetic resonance (MR) imaging transverse and longitudinal relaxation rates at 3.0 T in neonatal brain, the relationship between these rates, and their potential use for gray matter (GM) versus white matter (WM) tissue discrimination. MATERIALS AND METHODS: Informed parental consent for performance of imaging procedures was obtained in each infant. Informed consent for retrospective image analysis was not required; ethics approval was obtained from institutional review board. At 3.0 T, R1 and R2 were measured in brain regions (frontal WM, posterior WM, periventricular WM, frontal GM, posterior GM, basal ganglia, and thalamus) in 13 infants with suspected neurologic abnormality (two term, 11 preterm). Maps of R1 and R2 were acquired with T1 by multiple readout pulses and segmented spin-echo echo-planar imaging sequences, respectively. Accuracy of R1 and R2 map acquisition methods was tested in phantoms by comparing them with inversion-recovery and spin-echo sequences, respectively. Statistical analysis included linear regression analysis to determine relationship between R1 and R2 and Wilcoxon signed rank test to investigate the potential for discrimination between GM and WM. RESULTS: In phantoms, R1 values measured with T1 by multiple readout pulses sequence were 3%-8% lower than those measured with inversion recovery sequence, and R2 values measured with segmented echo-planar sequence were 1%-8% lower than those measured with spin-echo sequence. A strong correlation of 0.944 (P < .001) between R1 and R2 in neonatal brain was observed. For R2, relative differences between GM and WM were larger than were those for R1 (z = -2.366, P < .05). For frontal GM and frontal WM, (R2(GM) - R2(WM))/R2(WM) yielded 0.8 +/- 0.2 (mean +/- standard deviation) and (R1(GM) - R1(WM))/R1(WM) yielded 0.3 +/- 0.09. CONCLUSION: Results at 3.0 T indicate that R1 decreases with increasing field strength, while R2 values are similar to those reported at lower field strengths. For neonates, R2 image contrast may be more advantageous than R1 image contrast for differentiation between GM and WM.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".