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Record W2126176736 · doi:10.1177/0883911511398713

Synthesis and characterization of polyurethane- <i>block</i> -poly(2-hydroxyethyl methacrylate) hydrogels and their surface modification to promote cell affinity

2011· article· en· W2126176736 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueJournal of Bioactive and Compatible Polymers · 2011
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicHydrogels: synthesis, properties, applications
Canadian institutionsWestern University
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsPolyurethaneMethacrylate2-Hydroxyethyl MethacrylateSelf-healing hydrogelsPolymer chemistryMaterials science(Hydroxyethyl)methacrylateAdsorptionFibronectinTissue engineeringSurface modificationChemical engineeringChemistryPolymerCopolymerCellBiomedical engineeringOrganic chemistryComposite materialBiochemistry

Abstract

fetched live from OpenAlex

Physically crosslinked hydrogels based on poly(2-hydroxyethyl methacrylate) (PHEMA) and polyurethane macroiniferter (PUMI) were prepared. The synthesis of polyurethane- block-poly(2-hydroxyethyl methacrylate) (PU-b-PHEMA) was verified by spectroscopic analyses. Due to the low fibronectin adsorption from culture media, cell attachment on PU-b-PHEMA surface was poor compared with the PUMI control. To improve the cell affinity of PU-b-PHEMA, fibronectin was conjugated via surface hydroxyl groups. These biomimetic PU-b-PHEMA hydrogel surfaces were tested for tissue engineering applications. A short-term cell culture study revealed that, compared with the unmodified PU-b-PHEMA, fibronectin-conjugated PU-b-PHEMA hydrogel showed more uniform and dense cell attachment and spreading, indicating a potential use for tissue engineering applications.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.016
Threshold uncertainty score0.666

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.230
Teacher spread0.206 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it