Pediatric Typical Vs. Atypical Celiac Disease: Correlation of Duodenal Histology With Tissue Transglutaminase Levels
Bibliographic record
Abstract
Background: Both the clinical presentation and the degree of mucosal damage in coeliac disease vary greatly. In view of conflicting information as to whether the mode of presentation correlates with the degree of villous atrophy, we reviewed a 103 pediatric patient with coeliac disease. This study also aimed to determine the correlation of anti tTG level and the degree of mucosal damage in typical and atypical cases. Methods: The medical records of patients with newly diagnosed CD during the period of 2006 - 2010 were retrospectively reviewed. Results: A total of 103 patients fulfilled the established CD diagnostic criteria (mean age: 6.6 years; mediana: 5 years). A typical CD presentation was observed for 66/103 ( 64 .1% ) children vs atypical 37/103 (35.9%). The levels of tTG antibody were correlated significantly with Marsh types in the entire population by Spearman rank correlation (r = 0.661, P < 0.0001), and separately for typical(r = 0.633, P < 0.001) and atypical (r = 0.574, P < 0.0001) groups. Histopathological evaluation of intestinal biopsies revealed total or subtotal VA in 44 patients (66.6%) in the typical group, and 24 patients (64.8%) in the atypical group. Partial VA was observed in 5 patients (7.5%) in the typical group and 1 (2.7%) patients in atypical group. There was no correlation of mode of presentation (typical and atypical) with the degree of villous atrophy by a non-parametric Mann-Whitney U test Z = -1.437, P = 0.151. Conclusion: There is a positive correlation between tTG antibody serum level and duodenal histopathology in typical as in atypical pediatric CD. The degree of villous atrophy did not correlate with the mode of presentation, indicating that factors other than the degree of villous atrophy must account for typical simptoms in coeliac disease. doi: http://dx.doi.org/10.4021/ijcp57w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".