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Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations
Sachiko Yoneyama, Yiran Guo, Matthew B. Lanktree, Michael R. Barnes, Clara C. Elbers, Konrad J. Karczewski, Sandosh Padmanabhan, Florianne Bauer, Jens Baumert, Amber L. Beitelshees, Gerald S. Berenson, Jolanda M.A. Boer, Gregory L. Burke, Brian E. Cade, Wei Chen, Rhonda M. Cooper‐DeHoff, Tom R. Gaunt, Christian Gieger, Yan Gong, Mathias Gorski, Nancy L. Heard‐Costa, Toby Johnson, Michael J. LaMonte, Caitrin W. McDonough, Keri L. Monda, N. Charlotte Onland‐Moret, Christopher P. Nelson, Jeffrey R. O’Connell, José M. Ordovás, Inga Peter, Annette Peters, Jonathan A. Shaffer, Haiqinq Shen, Erin N. Smith, Liz Speilotes, Fridtjof Thomas, Barbara Thorand, W. M. Monique Verschuren, Sonia S. Anand, Anna F. Dominiczak, Karina W. Davidson, Robert A. Hegele, Iris M. Heid, Marten H. Hofker, Gordon S. Huggins, Thomas Illig, Julie A. Johnson, Susan Kirkland, Wolfgang König, Taimour Langaee, Jeanne M. McCaffery, Olle Melander, Braxton D. Mitchell, Patricia B. Munroe, Sarah S. Murray, George Papanicolaou, Susan Redline, Muredach P. Reilly, Nilesh J. Samani, Nicholas J. Schork, Yvonne T. van der Schouw, Daichi Shimbo, Alan R. Shuldiner, Martin D. Tobin, Cisca Wijmenga, Salim Yusuf, Håkon Håkonarson, Leslie A. Lange, Ellen W. Demerath, Caroline S. Fox, Kari E. North, Alex P. Reiner, Brendan J. Keating, Kira C. Taylor
Bibliographic record
VenueHuman Molecular Genetics · 2013
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsWestern UniversityDalhousie UniversityHamilton Health SciencesMcMaster UniversityPopulation Health Research Institute
FundersEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Center for Advancing Translational SciencesNational Institute of Environmental Health SciencesNational Human Genome Research InstituteNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteNational Institute on AgingNational Center for Research ResourcesNational Institute of General Medical SciencesBritish Heart Foundation
KeywordsBiologyPopulation stratificationSingle-nucleotide polymorphismBody mass indexWaistWaist–hip ratioType 2 diabetesGenome-wide association studyGeneticsPopulationGenetic associationDemographyQuantitative trait locusInternal medicineGenotypeDiabetes mellitusGeneEndocrinologyMedicine
Abstract
OpenAlex records an abstract for this work, but it could not be fetched just now.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.763
Threshold uncertainty score1.000
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.180
GPT teacher head0.389
Teacher spread0.208 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
Study designNot applicable
Domainnot available
GenreReview
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations33
Published2013
Admission routes1
Has abstractyes