Poster 40 Cervical Dystonia Patient Registry for Observation of Botox Efficacy (CD PROBE): Interim Results of Pain‐related Outcomes
Bibliographic record
Abstract
P. D. Charles, Allergan, research grants; Medtronic, research grants; Allergan, consulting fees or other remuneration; Medtronic, consulting fees or other remuneration; Pfizer, consulting fees or other remuneration. Interim analysis of pain-related outcomes in subjects who received repeated injections of onabotulinumtoxinA. A prospective, multicenter, observational patient registry. Neurology, pain, and rehabilitation clinics. Patients with a diagnosis of cervical dystonia (CD) who were candidates for botulinum toxin therapy and who were toxin naïve and/or new to the physicians' practices. Patients who had previously participated in a clinical trial that used botulinum toxin were permitted if the time since their last dose was ≥16 weeks. OnabotulinumtoxinA (3 injection cycles) with assessments at the time of injection and 4-6 weeks later. Measures of pain were the following: Pain Numeric Rating Scale (P-NRS), CD Impact Profile (CDIP-58), and the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) pain subscale. As of 10/11/2010, there were 499 subjects (77% women; mean age, 57.5±14.3 years; 94% Caucasian) available for this analysis. The mean age at symptom onset was 48.2±16.1 years, and the time to diagnosis was 5.4±8.6 years. The subjects reporting pain at baseline were 89.6% (440/491). Based on P-NRS, pain improved from 6.1±2.2 (baseline/visit 1) to 4.4±2.7 (end of study/visit 3) in study completers (n=84) with data available for each visit and baseline pain >0. Both repeated measures analysis of variance across visits and pairwise comparisons of baseline versus end of study visit scores (Hochberg adjusted P values) demonstrated statistically significant improvements in pain (P<.0001). The TWSTRS pain scale also showed significant improvement (P<.0001) in pain, from 10.9±5.3 (baseline/visit 1) to 7.5±5.5 (end of study/visit 3) in repeated measures and pairwise analyses in 131 subjects with data available for each visit. All domains for CDIP-58 improved significantly, including pain. The TWSTRS pain subscale correlated with CDIP-58 pain subscales (r=0.61) and P-NRS (r=0.78) (P<.0001 for both). Pain associated with CD is significantly improved after repeated onabotulinumtoxinA treatment sessions.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".