Comparison of long-term outcome of early versus late chronic phase imatinib receivers
Bibliographic record
Abstract
The introduction of imatinib mesylate made a remarkable contribution to the management of patients with chronic myeloid leukemia. In this study, we assessed the long-term efficacy of imatinib exposure in patients with CML in chronic phase according to European recommendations which consists both early and late chronic phase patients. This is a retrospective study including 101 chronic phase CML patients from a single center. The patient outcomes were analyzed according to initial treatment with imatinib either as firstline or secondline option following prior interferon. Kaplan-Meier curves were constructed to estimate probability and differences between subgroups were analyzed by the log-rank test. Forty-three percent of the patients had a prior history of interferon therapy. Of the 101 patients included, complete cytogenetic responses were achieved in 43.6 % of patients; major cytogenetic response in 55.4%; major molecular response in 36.6%. Totally, 21.3% had cytogenetic failure and 5.3% without any hematological response. Response rates were lower in late chronic phase patients compared to early chronic phase patients. This study justified the significance of ELN criteria and once again approved the high efficacy of imatinib treatment in chronic phase CML patients.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".