Primary Signet-Ring Cell Carcinoma of the Urinary Bladder in an Atomic Bomb Survivor: A Case Report
Bibliographic record
Abstract
Primary signet-ring cell carcinoma of the urinary bladder is a disorder with little detailed information because it has an extremely low incidence and an unfavorable prognosis. We report the case of an 80-year-old male patient with primary signet-ring carcinoma of the bladder. The patient was a long-lived atomic bomb survivor of Hiroshima. He complained of asymptomatic gross hematuria while under successful endocrine treatment for organ-confined prostate cancer. Magnetic resonance imaging showed diffuse thickening of the urinary bladder. Pathological specimens revealed an infiltrating growth of neoplastic cells with a signet-ring cell configuration. The o ral administration of t egafur-uracil (200 mg/m 2 per day) was initiated; however, the effect of this treatment was temporary. Fourteen months after the start of this treatment, the tumor had involved the bilateral intramural ureters and postrenal azotemia occurred because of bilateral hydronephrosis. Whether the prevalence of signet-ring cell carcinoma in the genitourinary tract is higher in atomic bomb survivors than in the general population remains much debated. The development of this rare and peculiar urothelial cancer after exposure to atomic bombing may give hints to the carcinogenic effect of ionizing radiation. doi: http://dx.doi.org/10.4021/wjnu99w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".